Long-Acting Osteoarthritis Knee Pain Relief

To those who don’t suffer from them, sore knees might not sound so bad. But people who are afflicted with knee pain know it can interfere with all sorts of physical activity including very basic ones because we bend and use our knees whenever we walk, sit, get in or out of the car, bed, or the tub, dress, do housework, pick up and carry things, or go up and down stairs. Thus, knee pain can detract from a person’s quality of life frequently if not constantly. It can even keep you from lying comfortably in bed and getting a good night’s sleep. Some of the most severe and enduring knee pain comes from osteoarthritis.


Osteoarthritis is a form of degenerative joint disease. It’s a deterioration of the cartilage in the joint and eventually of the underlying bone. The most common symptoms are joint pain and stiffness, but sufferers may also experience swelling and decreased range of motion, a grinding or clicking sound when flexing the joint, and problems bending or straightening a limb. Early on in the progression of osteoarthritis, the symptoms may occur only after exertion, but in the later stages, pain and other symptoms can become constant.

Exercise, weight loss for those who are overweight, and other measures to reduce stress on joints can sometimes slow the progression of osteoarthritis and achieve symptom relief. But for those whose osteoarthritis is producing knee pain and who need additional help to cope with that discomfort, PRI has treatment options to help.


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What Is Zilretta?


You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide or any other component of the product.

Before starting on Zilretta, let the doctor know if you have (or have had) an active or chronic infection including tuberculosis, ITP, stroke, heart disease, heart attack, hypertension, glaucoma, cataracts, or herpes infections of the eyes, a nerve-muscle disorder like myasthenia gravis, liver or kidney disease, a colostomy, ileostomy, or stomach surgery, diabetes, a stomach or intestinal disorder, low bone mineral density, or problems with your thyroid or adrenal glands. Also let your doctor know if you’re pregnant and be sure to inform him or her about all your current medications.

Indication and Important Risk Information

ZILRETTA® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

  • Rare serious allergic reactions
  • Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
  • Increased chance of getting an infection, and a decreased ability to fight an infection
  • Effects on hormone production. These effects can be reversible
  • Elevated blood pressure, sodium and water retention, and potassium loss
  • Intestinal perforation if you have certain gastrointestinal disorders
  • Weakening of bones
  • Changes in behavior or mood disturbances
  • Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report side effects to the FDA: Call 1-800-FDA-1088 (332-1088), or visit www.fda.gov/medwatch. You may also report side effects to Flexion at 1-844-FLEXION (353-9466).