Long-Acting Osteoarthritis Knee Pain Relief

To those who don’t suffer from them, sore knees might not sound so bad. But people who are afflicted with knee pain know it can interfere with all sorts of physical activity including very basic ones because we bend and use our knees whenever we walk, sit, get in or out of the car, bed, or the tub, dress, do housework, pick up and carry things, or go up and down stairs. Thus, knee pain can detract from a person’s quality of life frequently if not constantly. It can even keep you from lying comfortably in bed and getting a good night’s sleep. Some of the most severe and enduring knee pain comes from osteoarthritis. Fortunately, a Zilretta knee injection can bring relief.

Zilretta and Osteoarthritis

Osteoarthritis is a form of degenerative joint disease. It’s a deterioration of the cartilage in the joint and eventually of the underlying bone. The most common symptoms are joint pain and stiffness, but sufferers may also experience swelling and decreased range of motion, a grinding or clicking sound when flexing the joint, and problems bending or straightening a limb. Early on in the progression of osteoarthritis, the symptoms may occur only after exertion, but in the later stages, pain and other symptoms can become constant.

Exercise, weight loss for those who are overweight, and other measures to reduce stress on joints can sometimes slow the progression of osteoarthritis and achieve symptom relief. But for those whose osteoarthritis is producing knee pain and who need additional help to cope with that discomfort, there’s Zilretta.


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What Is Zilretta?

Zilretta knee injections for osteoarthritis pain relief are a potent weapon in the Pain Relief Institute’s comprehensive array of pain management therapies. Zilretta is a steroid that hinders the release of substances in the body that cause inflammation. In addition to providing relief from osteoarthritis knee pain, Zilretta is used to treat other inflammatory conditions including severe allergic reactions, blood cell, lung, and eye disorders, inflammation of the joints and tendons, and conditions produced by low adrenal gland hormones. It’s also used to address certain skin disorders resulting from autoimmune conditions like psoriasis, lupus, and lichen planus.

Zilretta injections provide slow-release pain medication that works for up to three months. In a clinical study, 70% of those treated with Zilretta reported zero to only mild knee pain after twelve weeks of treatment.


You shouldn’t take Zilretta if you’re allergic to it and may not be able to take it if you have a fungal infection or idiopathic thrombocytopenic purpura (ITP).

Before starting on Zilretta, let the doctor know if you have (or have had) an active or chronic infection including tuberculosis, ITP, stroke, heart disease, heart attack, hypertension, glaucoma, cataracts, or herpes infections of the eyes, a nerve-muscle disorder like myasthenia gravis, liver or kidney disease, a colostomy, ileostomy, or stomach surgery, diabetes, a stomach or intestinal disorder, low bone mineral density, or problems with your thyroid or adrenal glands. Also let your doctor know if you’re pregnant and be sure to inform him or her about all your current medications.


To take Zilretta knee injections and have the best possible outcome, following a treatment, don’t immediately go out and overuse your knee in high-impact sports or other strenuous exercise. You could damage your knee.

Stay away from sick people and people who have infections. Especially avoid people with measles or chickenpox and call your doctor for preventive treatment if you end up in contact with them anyway.

Don’t take a “live” or toxic vaccination while you’re on Zilretta. Such vaccinations include those for rubella (MMR), mumps, measles, typhoid, rotavirus, chickenpox, yellow fever, and shingles. You could contract an infection if you do.

There’s no need to live with osteoarthritis knee pain. Zilretta can help. Contact the Pain Relief Institute for a consultation.